Terminal Schwann cells at the human neuromuscular junction
نویسندگان
چکیده
منابع مشابه
Schwann cells: Dynamic roles at the neuromuscular junction
Neuroscientists generally assume that synapses have two components: a presynaptic nerve terminal apposed to a postsynaptic specialization — a specialized region of the postsynaptic membrane with a high density of receptors for neurotransmitter molecules released from the nerve terminal. In the case of the ‘simplest’ synapse of them all, the neuromuscular junction, recent work suggests that this...
متن کاملNeurally evoked calcium transients in terminal Schwann cells at the neuromuscular junction.
We examined the effects of motor-nerve stimulation on the intracellular Ca2+ levels of Schwann cells, the glial cells at the frog neuromuscular junction. Schwann cells, which were loaded with the fluorescent Ca2+ indicator fluo-3 and examined by confocal microscopy, showed a transient increase in free Ca2+ within a few seconds of the onset of tetanic stimulation of the motor nerve. The Ca2+ res...
متن کاملRegulation of terminal Schwann cell number at the adult neuromuscular junction.
Terminal Schwann cells (TSCs), neuroglia that cover motoneuron terminals, play a role in regulating the structure and function of the neuromuscular junction. In rats, the number of TSCs at each junction increases rapidly in early postnatal life and more slowly in young adults. It is possible that TSC number increases to match increasing endplate area. Alternatively, the increase in TSC number m...
متن کاملSchwann Cells in Neuromuscular Junction Formation and Maintenance.
UNLABELLED The neuromuscular junction (NMJ) is a tripartite synapse that is formed by motor nerve terminals, postjunctional muscle membranes, and terminal Schwann cells (TSCs) that cover the nerve-muscle contact. NMJ formation requires intimate communications among the three different components. Unlike nerve-muscle interaction, which has been well characterized, less is known about the role of...
متن کاملSchwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1.
Recent studies suggest that glial cells actively participate in the formation, function, maintenance, and repair of the chemical synapse. However, the molecular mechanisms of glia-synapse interactions are largely unknown. We have shown previously that Schwann cell-conditioned medium (SC-CM) promotes synaptogenesis in Xenopus nerve-muscle cocultures. The present study aimed to identify the synap...
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ژورنال
عنوان ژورنال: Brain Communications
سال: 2021
ISSN: 2632-1297
DOI: 10.1093/braincomms/fcab081